Sep 28, 2026, medRxiv, genetic and genomic medicine
Virus-induced epigenetic changes in stem-cell differentiation pathways emerge here as a shared mechanism linking fundamentally different chronic diseases, offering candidate biomarkers and new intervention targets. Chronic diseases increasingly trace back to transient viral exposure, yet unrelated pathologies also arise in tissues showing no signs of infection. Using Epstein-Barr virus (EBV), I show that different chronic EBV-associated diseases share epigenetic misprogramming within stem-cell differentiation hierarchies. These alterations propagate across diverse cell lineages, creating latent vulnerabilities unmasked by secondary insults. Breast cancer, long debated for possible EBV involvement, carries EBV-like methylation signatures in both precursor and invasive lesions, independent of lymphocytic infiltration. In multiple sclerosis, three independent cohorts (non-pathologic brain tissue, normal-appearing white matter, and blood) showed methylation abnormalities in the same stem-cell differentiation pathways disrupted in proven EBV-driven tumors and breast cancer. These findings identify virus-induced lineage misprogramming as an occult cross-disease mechanism supported by direct primary evidence.Show more
About the bioRxiv tool
Search preprints finds bioRxiv and medRxiv preprints matching topic words in titles, abstracts, and subject categories.
Provide topic words and optionally a server, posting date range, and result limit; results appear newest first, with journal details when available.
Built from biorxiv.org. Last checked Sep 29, 2026.
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Search preprints
1 credit
Find bioRxiv and medRxiv preprints matching topic words within a posting date range, newest first. Published journal details appear when available.
What you provide
Field
Type
Required
Description
Queryquery
Text
Required
Topic words to find in preprint titles, abstracts, and subject categories, for example gut microbiome depression.Example: breast cancer
Serverserver
Text
Optional
Preprint server to search, for example both.Example: Medrxiv
End Dateend_date
Date
Optional
Last posting date, inclusive, for example 2026-09-29. Defaults to today.Example: 2026-09-28
Start Datestart_date
Date
Optional
First posting date, inclusive, for example 2026-09-01. Defaults to 30 days before today.Example: 2026-09-27
Max Resultsmax_results
Number
Optional
Maximum number of matching preprints, for example 20.Example: 5
Preprint title.Example: Pixel-Level Quantification of Subcutaneous Shear-Wave Velocity Heterogeneity…
Serverpreprints[].server
Text
bioRxiv or medRxiv.Example: medRxiv
Authorspreprints[].authors
Text
Authors as credited by the preprint server.Example: Hoe, Z. Y.; Chou, C.-P.; Tzeng, Y.-D.; Ding, R.-S.; Pan, C.-T.; Lee, M.-C…
Journalpreprints[].journal
Text
Journal name if subsequently published.Example: G3: Genes|Genomes|Genetics
Abstractpreprints[].abstract
Text
Plain-text abstract.
PDF Linkpreprints[].pdf_link
Text
Direct link to the preprint PDF.Example: https://www.medrxiv.org/content/10.64898/2026.09.25.26364003v0.full.pdf
Date Postedpreprints[].date_posted
Date
Date this version was posted.Example: 2026-09-28
Journal Linkpreprints[].journal_link
Text
Published journal article link if available.Example: https://doi.org/10.1093/g3journal/jkac008
Preprint Linkpreprints[].preprint_link
Text
Page for this preprint version.Example: https://www.medrxiv.org/content/10.64898/2026.09.25.26364003v0
Subject Categorypreprints[].subject_category
Text
Subject area.Example: radiology and imaging
Example result
For Query: breast cancer, Server: Medrxiv, End Date: 2026-09-28, Start Date: 2026-09-27, Max Results: 5
JSON
{"preprints":[{"doi":"10.64898/2026.09.25.26364003","title":"Pixel-Level Quantification of Subcutaneous Shear-Wave Velocity Heterogeneity for Grading Lymphatic Obstruction in Breast Cancer-Related Lymphedema","server":"medRxiv","authors":"Hoe, Z. Y.; Chou, C.-P.; Tzeng, Y.-D.; Ding, R.-S.; Pan, C.-T.; Lee, M.-C.; Lee, C.-H.","journal":null,"abstract":"Objectives: To develop and validate pixel data analysis (PDA) for reconstructing pixel-level shear-wave velocity (SWV) from saved Holder-Optimized Elastography (HOE) elastograms and to determine wheth…","pdf_link":"https://www.medrxiv.org/content/10.64898/2026.09.25.26364003v0.full.pdf","date_posted":"2026-09-28","journal_link":null,"preprint_link":"https://www.medrxiv.org/content/10.64898/2026.09.25.26364003v0","subject_category":"radiology and imaging"},{"doi":"10.64898/2026.09.08.26362522","title":"Epigenetic misprogramming of cell differentiation links transient viral infection to chronic diseases across tissues","server":"medRxiv","authors":"Friedenson, B.","journal":null,"abstract":"Virus-induced epigenetic changes in stem-cell differentiation pathways emerge here as a shared mechanism linking fundamentally different chronic diseases, offering candidate biomarkers and new interve…","pdf_link":"https://www.medrxiv.org/content/10.64898/2026.09.08.26362522v0.full.pdf","date_posted":"2026-09-28","journal_link":null,"preprint_link":"https://www.medrxiv.org/content/10.64898/2026.09.08.26362522v0","subject_category":"genetic and genomic medicine"}]}
For developers
Call it from your code with one request. Change the values in input to run it on new data. To get an API key, open Developers at the bottom of Studio, turn on Developer mode and go to API keys.
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Can I call this bioRxiv tool as an API?
Yes. Send a POST request to /v1/query with your Fous API key and the inputs, and get JSON back.
How much does it cost?
Each completed run costs 1 credit. Failed runs without a completed receipt are free; completed work can remain charged if delivery is interrupted. With pay as you go, a credit costs 1¢. Monthly plans cost less per credit.
Do I need a bioRxiv account?
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How current is the data?
Fous gets the data from biorxiv.org when you run it. Some results are reused for up to 24 hours, and results that use your account or key are never reused. It was last verified on Sep 29, 2026.
Which preprints match my research topic?
Search preprints finds preprints matching topic words in titles, abstracts, and subject categories.
When was a preprint posted?
Search preprints returns the posting date for each matching version.
Has a preprint been published in a journal?
Search preprints includes journal details and a journal article link when available.